污染物风险评估及控制

元素生物地球化学循环

环境生物技术与微生物生态学

2025年至2026年，南方典型淡水水产养殖塘抗生素抗性基因的分布特征、生态风险及驱动机制，区域环境安全全国重点实验室(北京大学)自由研究课题，课题负责人

2023年至2025年，内河环境污染事故应急与生态风险管控技术研究，国家重点研发计划政府间国际科技创新合作项目，任务负责人

2023年至2026年，红树林生态系统监测评估与修复技术研究与应用示范，深圳市可持续发展科技专项项目，核心成员

2021年至2023年，生物处理工艺对新型污染物亚硝胺和抗生素的代谢机理，环境模拟与污染控制国家重点联合实验室联合基金，项目共同负责人

2018年至2021年，人工湿地系统中磺胺类抗生素的生物降解机制和生物强化去除研究，国家自然科学基金面上项目，项目负责人

2018年至2021年，梯级开发对澜沧江氮迁移转化的影响机制及生态环境累积效应研究，国家自然科学基金重大研究计划重点支持项目，技术负责人

2024年 北京大学正大奖教金

2019年 北京大学杨芙清-王阳元院士教师奖优秀奖

2014年 北京大学黄廷芳/信和青年杰出学者奖

代表性论文

Jianfei Chen, Xiuli Chen, Ying Zhu, Shuang Yan, Shuguang Xie* (2024) New insights into bioaugmented removal of sulfamethoxazole in sediment microcosms: degradation efficiency, ecological risk and microbial mechanisms. Microbiome 12:43

Yanchu Ke, Wenjun Sun*, Yanei Xue, Ying Zhu, Shuang Yan, Shuguang Xie* (2024) Effects of treatments and distribution on microbiome and antibiotic resistome from source to tap water in three Chinese geographical regions based on metagenome assembly. Water Research 249:120894

Yanchu Ke, Wenjun Sun*, Zhongyun Chen, Ying Zhu, Xiuli Chen, Shuang Yan, Yangyang Li, Shuguang Xie* (2024) Effects of disinfectant type and dosage on biofilm’s activity, viability, microbiome and antibiotic resistome in bench-scale drinking water distribution systems. Water Research 249:120958

Jianfei Chen, Yanchu Ke, Ying Zhu, Xiuli Chen, Shuguang Xie* (2023) Deciphering of sulfonamide biodegradation mechanism in wetland sediments: from microbial community and individual populations to pathway and functional genes. Water Research 240:120132

Xiuli Chen, Ying Zhu, Jianfei Chen, Shuang Yan, Shuguang Xie*(2023) Multi-omic profiling of a novel activated sludge strain Sphingobacterium sp. WM1 reveals the mechanism of tetracycline biodegradation and its merits of potential application. Water Research 243:120397

Yanchu Ke, Wenjun Sun^*, Xiuli Chen, Ying Zhu, Xu Guo, Weixin Yan,Shuguang Xie^* (2023) Seasonality determines the variations of biofilm microbiome and antibiotic resistome in a pilot-scale chlorinated drinking water distribution system deciphered by metagenome assembly. Environmental Science & Technology 57(31):11430-11441

Yanchu Ke, Wenjun Sun*, Shuming Liu, Ying Zhu, Shuang Yan, Xiuli Chen, Shuguang Xie* (2023) Seasonal variations of biofilm C, N and S cycling genes in a pilot-scale chlorinated drinking water distribution system. Water Research 247:120759

Ying Zhu, Yi Zhang, Shuang Yan, Xiuli Chen, Shuguang Xie* (2023) Viral community structure and functional potential vary with lifestyle and altitude in soils of Mt. Everest. Environment International 178:108055

Jianfei Chen, Yuyin Yang, Yanchu Ke, Xiuli Chen, Xinshu Jiang, Chao Chen, Shuguang Xie* (2022) Sulfonamide-metabolizing microorganisms and mechanisms in antibiotic-contaminated wetland sediments revealed by stable isotope probing and metagenomics. Environment International 165:107332

Jianfei Chen, Yuyin Yang, Yanchu Ke, Xiuli Chen, Xinshu Jiang, Chao Chen, Shuguang Xie*(2022) Anaerobic sulfamethoxazole-degrading bacterial consortia in antibiotic-contaminated wetland sediments identified by DNA-stable isotope probing and metagenomics analysis. Environmental Microbiology 24(8):3751-3763