1. First-principles thinking re-evaluates seawater desalination as a transformative solution to water scarcity.
2. 100-Kilometer Coastal Desalination for Short-cut water cycle (100K-CDS) strategy was proposed.
3. Overcoming public perception gaps and techno-economic barriers unlocks large-scale desalination potential.
4. Renewable energy sources could remarkably reduce desalination’s carbon footprint.